RT Journal Article
SR Electronic
T1 Mifepristone May Halt Progression of Extensively Metastatic Human Adenocarcinoma of the Colon - Case Report
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1611
OP 1613
VO 29
IS 5
A1 CHECK, JEROME H.
A1 DIX, EBONY
A1 SANSOUCIE, LYNN
A1 CHECK, DIANE
YR 2009
UL http://ar.iiarjournals.org/content/29/5/1611.abstract
AB Background: Mifepristone, a progesterone receptor antagonist has been found to improve the length and quality of life in various spontaneous murine cancer models including tumors without progesterone receptors theoretically by inhibiting an immunomodulatory protein that suppresses natural killer cell function in the tumor microenvironment. Materials and Methods: Mifepristone 200 mg per day by mouth was given to two patients with stage 4 colon cancer with extensive metastases. Results: Both patients not only survived far longer than expected but had marked improvement in their quality of life similar to mice. Though the metastatic lesions did not disappear, no new ones appeared for a long time and the ones present did not grow. The drug was extremely well tolerated. Conclusion: The use of progesterone receptor antagonists may present a novel immunotherapy to help fight cancer. A larger controlled study is needed.