TY - JOUR T1 - Genetic and Molecular Abnormalities in Cholangiocarcinogenesis JF - Anticancer Research JO - Anticancer Res SP - 1151 LP - 1156 DO - 10.21873/anticanres.16345 VL - 29 IS - 4 AU - VICTOR J. HASSID AU - FRANK A. ORLANDO AU - ZIAD T. AWAD AU - DONGFENG TAN AU - THAER KHOURY AU - BESTOUN H. AHMED AU - SADIR J. ALRAWI Y1 - 2009/04/01 UR - http://ar.iiarjournals.org/content/29/4/1151.abstract N2 - Cholangiocarcinomas are biliary tree neoplasms of cholangiocyte origin. Several clinical risk factors are associated with cholangiocarcinogenesis. During the last decade, there has been an increasing interest in the causative molecular mechanisms of cholangiocarcinoma because of its poor prognosis and the lack of effective therapies. A better understanding of cholangiocarcinoma tumor initiation, promotion, and progression, as well as neurotransmitter, neuroendocrine, and endocrine growth effects, may elucidate molecular targets for diagnostic and therapeutic purposes. ER -