@article {FREDERIKSEN75, author = {C. FREDERIKSEN and A.F. LOMHOLT and G.J. DAVIS and B.L. DOWELL and M.A. BLANKENSTEIN and I.J. CHRISTENSEN and N. BR{\"U}NNER and H.J. NIELSEN}, title = {Changes in Plasma TIMP-1 Levels after Resection for Primary Colorectal Cancer}, volume = {29}, number = {1}, pages = {75--81}, year = {2009}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Increased plasma levels of tissue inhibitor of metalloproteinases (TIMP-1) are associated with poor outcome in colorectal cancer (CRC), however postoperative changes in plasma TIMP-1 levels after resections for CRC have not been thoroughly evaluated. Materials and Methods: Plasma samples were collected from 45 patients with primary CRC, preoperatively, 2 hours after surgery, and at days 1, 2, 7, 28, 45, 60, 75 and 90 after surgery. TIMP-1 and CEA levels were determined using the ARCHITECT{\textregistered} Immunoanalyzer. Results: Postoperatively, the mean (geometric) TIMP-1 level increased and had a maximum level at day 1 (p\<0.0001). The mean TIMP-1 level then declined to a level at day 90 similar to the mean preoperative level. Conclusion: A mean decline in plasma TIMP-1 levels was not observed within 90 days. However, individual significant reductions of plasma TIMP-1 levels did occur within 28-60 days postoperatively. Copyright{\textcopyright} 2009 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/29/1/75}, eprint = {https://ar.iiarjournals.org/content/29/1/75.full.pdf}, journal = {Anticancer Research} }