RT Journal Article
SR Electronic
T1 Elevated Neutrophil–to–Lymphocyte-ratio and Platelet–to–Lymphocyte Ratio in Myelofibrosis: Inflammatory Biomarkers or Representatives of Myeloproliferation Itself?
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3157
OP 3163
VO 38
IS 5
A1 MARKO LUCIJANIC
A1 DAVID CICIC
A1 TAJANA STOOS-VEIC
A1 VLATKO PEJSA
A1 JELENA LUCIJANIC
A1 AMINA FAZLIC DZANKIC
A1 JOSIPA VLASAC GLASNOVIC
A1 ENA SORIC
A1 MARKO SKELIN
A1 RAJKO KUSEC
YR 2018
UL http://ar.iiarjournals.org/content/38/5/3157.abstract
AB Background/Aim: We aimed to investigate clinical associations of inflammatory biomarkers neutrophil-to-lymphocyte-ratio (NLR) and platelet-to-lymphocyte-ratio (PLR) in patients with myelofibrosis, myeloproliferative neoplasm with inflammatory background. Patients and Methods: We retrospectively analyzed a cohort of 102 myelofibrosis patients. NLR and PLR were assessed in addition to other disease-specific parameters. Results: NLR and PLR were significantly higher in myelofibrosis than in healthy controls. Higher NLR was significantly associated with Janus-kinase-2 (JAK2)-mutation, wild-type-Calreticulin (CALR), older age and parameters reflecting increased proliferative potential of disease (higher leukocytes, higher hemoglobin, larger spleen-size), whereas there was no significant association with C-reactive-protein (CRP). Higher PLR was significantly associated with absence of blast-phase-disease, absence of constitutional-symptoms, lower percentage-of-circulatory-blasts, smaller spleen-size and lower CRP. In the Cox-regression-model, higher-NLR (HR=2.76; p=0.004), lower-PLR (HR=1.99; p=0.042) and Dynamic-International-Prognostic-System (DIPSS) (HR=3.26; p<0.001) predicted inferior survival independently of each other. Conclusion: In the context of myelofibrosis, elevated NLR and PLR are more likely to represent myeloproliferation itself and not necessary the extent of inflammation.