TY - JOUR T1 - Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age JF - Anticancer Research JO - Anticancer Res SP - 381 LP - 386 DO - 10.21873/anticanres.13123 VL - 39 IS - 1 AU - AVALON ERNSTSON AU - KATRIN CHRISTINE ASCIUTTO AU - JOHAN STURESSON AU - JONAS NORÉN AU - OLA FORSLUND AU - CHRISTER BORGFELDT Y1 - 2019/01/01 UR - http://ar.iiarjournals.org/content/39/1/381.abstract N2 - Background/Aim: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. Materials and Methods: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in ≥5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. Results: The self-sample response rate was 43.3%. The HPV mRNA prevalence was 6.2%. All HPV-positive women attended follow-up. Conclusion: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer. ER -