@article {ERNSTSON381, author = {AVALON ERNSTSON and KATRIN CHRISTINE ASCIUTTO and JOHAN STURESSON and JONAS NOR{\'E}N and OLA FORSLUND and CHRISTER BORGFELDT}, title = {Detection of HPV mRNA in Self-collected Vaginal Samples Among Women at 69-70 Years of Age}, volume = {39}, number = {1}, pages = {381--386}, year = {2019}, doi = {10.21873/anticanres.13123}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. Materials and Methods: An HPV self-sampling kit was sent to 1,000 women 69-70 years whom had not taken a cervical smear in >=5 years. The samples were analyzed by the Aptima HPV mRNA assay. HPV-positive women were recalled for a follow-up examination. Results: The self-sample response rate was 43.3\%. The HPV mRNA prevalence was 6.2\%. All HPV-positive women attended follow-up. Conclusion: HPV self-sampling was accepted among older women. Although the HPV mRNA prevalence was 6.2\%, no high-grade cytological abnormalities were found. Larger studies are needed to elucidate hr-HPV self-sampling as a tool to identify older women at risk of cervical cancer.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/39/1/381}, eprint = {https://ar.iiarjournals.org/content/39/1/381.full.pdf}, journal = {Anticancer Research} }