TY - JOUR T1 - No Ink on Ductal Carcinoma <em>In Situ</em>: A Single Centre Experience JF - Anticancer Research JO - Anticancer Res SP - 459 LP - 466 DO - 10.21873/anticanres.13134 VL - 39 IS - 1 AU - PIERO FREGATTI AU - MARCO GIPPONI AU - FRANCESCA DEPAOLI AU - FEDERICA MURELLI AU - MARINA GUENZI AU - ELISABETTA BONZANO AU - MARCELLO CEPPI AU - DANIELE FRIEDMAN Y1 - 2019/01/01 UR - http://ar.iiarjournals.org/content/39/1/459.abstract N2 - Background/Aim: A retrospective analysis of 388 patients with pure ductal carcinoma in situ (DCIS) was performed in order to test the correlation of clearance margin of resection and other host-, tumor- and treatment-related factors with ipsilateral breast tumor recurrence (IBTR). Materials and Methods: The pathological analysis was performed according to a standardized protocol: positive margins had DCIS at the inked margin; close margins had tumor between 0.1 to 0.9 mm, or 1 to 1.9 mm, and negative margins were ≥2 mm. Results: At a median follow-up of 90 months there were 26 IBTR (10 invasive and 16 DCIS). Both in univariate and multivariate analysis a significant difference was observed in IBTR by comparing positive versus close/negative margins of excision (p=0.05) and the number of re-operations (p=0.000). Moreover, the actuarial IBTR rates were significantly different in patients with a positive compared to close/negative margins (log-rank test, p=0.042) while the stratification by the margin width (0.1-0.9 mm; 1.0-1.9 mm; ≥2 mm) was not significant (log-rank test, p=0.243). Conclusion: The policy of “no ink on the tumor” can be translated from invasive to DCIS, because the actuarial IBTR rates were significantly different only in patients with a positive, compared to close/negative margins. ER -