PT - JOURNAL ARTICLE AU - ALESSIA AGUZZI AU - DANIELE MAGGIONI AU - GABRIELLA NICOLINI AU - GIOVANNI TREDICI AU - RENATO MARIA GAINI AU - WERNER GARAVELLO TI - MAP Kinase Modulation in Squamous Cell Carcinoma of the Oral Cavity DP - 2009 Jan 01 TA - Anticancer Research PG - 303--308 VI - 29 IP - 1 4099 - http://ar.iiarjournals.org/content/29/1/303.short 4100 - http://ar.iiarjournals.org/content/29/1/303.full SO - Anticancer Res2009 Jan 01; 29 AB - Background: Oral squamous cell carcinoma (OSCC) represents the sixth most diffused cancer in developed countries. Mitogen-activated protein kinases (MAPKs) are proteins which transduce a vast array of extracellular signals into intracellular responses. The role of MAPK signalling pathway in cancer is not completely understood. Materials and Methods: In this study, we attempted to specifically evaluate the activation state of MAPK in OSCC. MAPK expression and activation were analyzed by immunoblotting in thirty tissue samples of OSCC and their paired nonneoplastic perilesional tissues. On the same tissues, the activation and expression of MAPK JNK/SAPK were also evaluated by ELISA assay. Results: Analyzing the levels of phospho-ERK1/2p44/p42, a statistically significant reduction was observed in tumors compared to normal tissues. No statistically significant difference between tumor and control tissue was found for p38MAPK or JNK/SAPK. Conclusion: These results suggest that a reduction in ERK1/2p44/p42 phosphorylation is correlated with tumor growth in OSCC. Copyright© 2009 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved