RT Journal Article SR Electronic T1 Significant Association of DNA Repair Gene Ku80 Genotypes with Breast Cancer Susceptibility in Taiwan JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 5251 OP 5254 VO 29 IS 12 A1 HWEI-CHUNG WANG A1 CHIU-SHONG LIU A1 CHANG-FANG CHIU A1 SU-YIN CHIANG A1 CHUNG-HSING WANG A1 ROU-FEN WANG A1 CHENG-CHIEH LIN A1 RU-YIN TSAI A1 DA-TIAN BAU YR 2009 UL http://ar.iiarjournals.org/content/29/12/5251.abstract AB Aim: To evaluate the association between the genotypes of the heterodimeric DNA-binding component, Ku80 gene and the breast cancer risk in Taiwan. Patients and Methods: In this hospital-based case-control study, the association of Ku80 G-1401T rs828907, Ku80 C-319T rs11685387 and Ku80 intron19 rs9288518 polymorphisms with breast cancer risk in a Taiwanese population was investigated. In total, 1272 patients with breast cancer and the same number of age- and gender-matched healthy controls were genotyped. Results: A significantly different distribution was found in the frequency of the Ku80 G-1401T genotype, but not the Ku80 C-319T or intron 19 genotypes, between the breast cancer and control groups. The T allele Ku80 G-1401T conferred a significant (p=0.0069) increased risk of breast cancer. Gene interactions with smoking, but not with breastfeeding, were significant for the Ku80 G-1401T polymorphism. The Ku80 G-1401T GT and TT genotypes in association with smoking conferred an increased risk of 3.162 (95% confidence interval=2.275-4.393) for breast cancer. Conclusion: The T allele of Ku80 G-1401T may be associated with the development of breast cancer and may be a novel useful marker for breast cancer detection and prediction.