TY - JOUR T1 - Claudin-5 Overexpression Correlates with Aggressive Behavior in Serous Ovarian Adenocarcinoma JF - Anticancer Research JO - Anticancer Res SP - 5185 LP - 5189 VL - 29 IS - 12 AU - M. TURUNEN AU - A. TALVENSAARI-MATTILA AU - Y. SOINI AU - M. SANTALA Y1 - 2009/12/01 UR - http://ar.iiarjournals.org/content/29/12/5185.abstract N2 - Background: Claudins are essential tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, and are responsible for the permeability of the paracellular space. The expression of claudin-5 and its correlation to ovarian cancer behavior was investigasted. Materials and Methods: A total of 85 serous ovarian cancer tissue samples were analyzed using immunohistochemical staining. Results: An association between claudin-5 expression and cancer grade (p=0.016) and advanced stage (p=0.022), strongest claudin-5 expression was found in advanced stage and high-grade carcinomas. An association between claudin-5 expression and cancer-specific (p=0.032) and overall survival (p=0.026) was also found. Only 25-30% of claudin-5-positive patients, but 60% of claudin-5-negative patiens were alive at the 5-years follow-up. Conclusion: Increased claudin-5 expression is associated with aggressive behavior in serous ovarian adenocarcinoma. ER -