PT  - JOURNAL ARTICLE
AU  - TURUNEN, M.
AU  - TALVENSAARI-MATTILA, A.
AU  - SOINI, Y.
AU  - SANTALA, M.
TI  - Claudin-5 Overexpression Correlates with Aggressive Behavior in Serous Ovarian Adenocarcinoma
DP  - 2009 Dec 01
TA  - Anticancer Research
PG  - 5185--5189
VI  - 29
IP  - 12
4099  - http://ar.iiarjournals.org/content/29/12/5185.short
4100  - http://ar.iiarjournals.org/content/29/12/5185.full
SO  - Anticancer Res2009 Dec 01; 29
AB  - Background: Claudins are essential tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, and are responsible for the permeability of the paracellular space. The expression of claudin-5 and its correlation to ovarian cancer behavior was investigasted. Materials and Methods: A total of 85 serous ovarian cancer tissue samples were analyzed using immunohistochemical staining. Results: An association between claudin-5 expression and cancer grade (p=0.016) and advanced stage (p=0.022), strongest claudin-5 expression was found in advanced stage and high-grade carcinomas. An association between claudin-5 expression and cancer-specific (p=0.032) and overall survival (p=0.026) was also found. Only 25-30% of claudin-5-positive patients, but 60% of claudin-5-negative patiens were alive at the 5-years follow-up. Conclusion: Increased claudin-5 expression is associated with aggressive behavior in serous ovarian adenocarcinoma.