PT - JOURNAL ARTICLE AU - YOSHINOBU MANOME AU - HIROSHI FURUHATA AU - AKIFUMI HASHIMOTO AU - NAOTAKE FUNAMIZU AU - RIE SUZUKI AU - SHO ISHIZAWA AU - NOBUTAKE AKIYAMA AU - TOSHIAKI KOBAYASHI AU - MICHIKO WATANABE TI - Application of Therapeutic Insonation to Malignant Glioma Cells and Facilitation by Echo-contrast Microbubbles of Levovist DP - 2009 Jan 01 TA - Anticancer Research PG - 235--242 VI - 29 IP - 1 4099 - http://ar.iiarjournals.org/content/29/1/235.short 4100 - http://ar.iiarjournals.org/content/29/1/235.full SO - Anticancer Res2009 Jan 01; 29 AB - Background: Malignancies affecting the central nervous system are intractable to conventional therapies thereby requiring an alternative strategy, such as ultrasound irradiation. Materials and Methods: We originally designed a transducer for intracranial insonation and investigated the effect of 210.4 kHz ultrasound on malignant glioma cells. Results: The insonation of 2.61 W/cm2 effectively disrupted the malignant cells. This effect was reinforced by the echo-contrast agent, Levovist. The condition was applied to tumor-bearing animals and external insonation inhibited subcutaneous tumor growth. It also repressed the growth of intracranially implanted tumors and prolonged survival of the animals. When Levovist was stereotactically injected into the tumors, the effect of insonation was significantly enhanced. Conclusion: A neuronavigation system or stereotactic device has been used commonly for patients with brain tumor. Administration of combination therapy consisting of insonation and a local echo-contrast agent will have a role in improving the treatment for malignant gliomas. Copyright© 2009 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved