<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MAESTRO, LUISA M.</style></author><author><style face="normal" font="default" size="100%">SASTRE, JAVIER</style></author><author><style face="normal" font="default" size="100%">RAFAEL, SARA B.</style></author><author><style face="normal" font="default" size="100%">VEGANZONES, SILVIA B.</style></author><author><style face="normal" font="default" size="100%">VIDAURRETA, MARTA</style></author><author><style face="normal" font="default" size="100%">MARTÍN, MIGUEL</style></author><author><style face="normal" font="default" size="100%">OLIVIER, CARLOS</style></author><author><style face="normal" font="default" size="100%">DE LA ORDEN, VIRGINIA B.</style></author><author><style face="normal" font="default" size="100%">GARCIA-SAENZ, JOSE ANGEL</style></author><author><style face="normal" font="default" size="100%">ALFONSO, ROSARIO</style></author><author><style face="normal" font="default" size="100%">ARROYO, MANUEL</style></author><author><style face="normal" font="default" size="100%">DIAZ-RUBIO, EDUARDO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Circulating Tumor Cells in Solid Tumor in Metastatic and Localized Stages</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4839-4843</style></pages><volume><style face="normal" font="default" size="100%">29</style></volume><issue><style face="normal" font="default" size="100%">11</style></issue><abstract><style  face="normal" font="default" size="100%">The aim of this study was the detection of circulating tumor cells (CTC) in three tumor types of epithelial origin. Patients and Methods: Four hundred and thirty-eight patients with breast cancer (56.2% localized and 43.8% metastatic), 195 with colorectal tumors (84.1% localized and 15.9% metastatic) and 50 with prostate cancer (52% localized and 48% metastatic) took part in this study. CTC quantification was performed using the CellSpotter Analyzer (Veridex® LLC). Results: 31.5% of patients with cancer had ≥2 CTCs/7.5 mL but none of the healthy volunteers were above this level (p&lt;0.001). Among patients with metastatic disease, 62.3% of them had ≥2 CTCs/7.5 mL but only 14.0% of those with localized disease were above this level (p&lt;0.001). The presence of CTCs were correlated to stage in the three studied tumor types and no differences in the number of cells were found between them. Conclusion: The presence of more than 2 CTCs/7.5 ml is a frequent event in metastatic cases. In particular, patients with localized disease who have more than 2 CTCs/7.5 ml should be carefully studied to determine the possible prognostic and predictive value of this finding.</style></abstract></record></records></xml>