RT Journal Article
SR Electronic
T1 Preoperative Chemotherapy with S-1 and Cisplatin for Highly Advanced Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4689
OP 4696
VO 29
IS 11
A1 NASHIMOTO, ATSUSHI
A1 YABUSAKI, HIROSHI
A1 NAKAGAWA, SATORU
A1 TAKII, YASUGIRO
A1 TSUCHIYA, YOSHIAKI
A1 OTSUO, TANAKA
YR 2009
UL http://ar.iiarjournals.org/content/29/11/4689.abstract
AB Feasibility and efficacy of S-1 and cisplatin followed by surgery was evaluated, and factors contributing to survival benefit were analyzed. Patients and Methods: In total, 120 consecutive patients with highly advanced gastric cancer were treated with S-1 (80 mg/m2 for 21 consecutive days) and cisplatin (50 mg/m2 on day 8). Results: The response rate was 62.5% overall, and 75.7% for these with metastatic lymph nodes. Grade 3/4 adverse events were less than 10%. The median survival time was 41.9 months among 93 patients whose primary lesion was resected. Liver metastasis, R2 resection, poor performance status and lack of response were identified as independent risk factors by a multivariate analysis. Conclusion: Preoperative chemotherapy with S-1 and cisplatin was effective. The results show the need for different approaches in the treatment of patients with metastases and these without.