RT Journal Article
SR Electronic
T1 Altered Glucose Metabolism During Chemoradiation for Head and Neck Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4683
OP 4687
VO 29
IS 11
A1 NGUYEN, NAM P.
A1 VOS, PAUL
A1 VINH-HUNG, VINCENT
A1 BOROK, THOMAS L.
A1 DUTTA, SURESH
A1 KARLSSON, ULF
A1 LEE, HOWARD
A1 MARTINEZ, TOMAS
A1 JO, BENG-HOEY
A1 NGUYEN, LY M.
A1 NGUYEN, NGA
A1 SALLAH, SABAH
YR 2009
UL http://ar.iiarjournals.org/content/29/11/4683.abstract
AB Platinum-based chemotherapy has been reported to induce diabetes and hyperosmolar coma in nondiabetic patients. The aim of the present study was to determine whether the administration of chemoradiation for head and neck carcinoma alters glucose metabolism during and after treatment. Patients and Methods: Weekly nonfasting serum glucose level was obtained during treatment of one hundred and six patients with locally advanced head and neck cancer who underwent chemoradiationt. Results: For the 91 non-diabetic patients, mean serum glucose level measured 97.75 before and 102.1, 102, 104.1, 109.1, 109.7, 110.3, 109.8, 113.2, 107.7 and 104.3 mg/dl during weeks 1-10 of treatment respectively. Serum glucose level elevation reached statistical significance for weeks 5-8. Conclusion: Chemoradiation for head and neck cancer may produce severe glucose metabolism alteration during treatment.