PT - JOURNAL ARTICLE AU - WARNECKE-EBERZ, UTE AU - BOLLSCHWEILER, ELFRIEDE AU - DREBBER, UTA AU - METZGER, RALF AU - BALDUS, STEPHAN E. AU - HÖLSCHER, ARNULF H. AU - MÖNIG, STEFAN TI - Prognostic Impact of Protein Overexpression of the Proto-oncogene <em>PIM-1</em> in Gastric Cancer DP - 2009 Nov 01 TA - Anticancer Research PG - 4451--4455 VI - 29 IP - 11 4099 - http://ar.iiarjournals.org/content/29/11/4451.short 4100 - http://ar.iiarjournals.org/content/29/11/4451.full SO - Anticancer Res2009 Nov 01; 29 AB - Background: PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma. Patients and Methods: Cancer tissues of 117 patients with potentially curative (R0) resections for gastric cancer were immunohistochemically stained for PIM-1. Results: Cytoplasmic immunoreactivity for PIM-1 in tumor (46%) was higher (p=0.003) compared to that in gastric glands (16%) and foveolae (1%). PIM-1 immunoreactivity in gastric carcinoma correlated with tumor grading (p&lt;0.05) and Laurén category (p&lt;0.02). Overexpression of PIM-1 in gastric glands (p&lt;0.001) was associated with formation of lymph node metastases (p=0.035) and survival (p=0.04). Multivariate analysis of PIM-1 expression in gastric glands confirmed its association with prognosis. Conclusion: Up-regulation of PIM-1 oncogene might be a tumor marker for gastric cancer. The correlation of PIM-1 overexpression in gastric glands with formation of lymph node metastases and survival proposes a prognostic role in gastric cancer.