<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">WARNECKE-EBERZ, UTE</style></author><author><style face="normal" font="default" size="100%">BOLLSCHWEILER, ELFRIEDE</style></author><author><style face="normal" font="default" size="100%">DREBBER, UTA</style></author><author><style face="normal" font="default" size="100%">METZGER, RALF</style></author><author><style face="normal" font="default" size="100%">BALDUS, STEPHAN E.</style></author><author><style face="normal" font="default" size="100%">HÖLSCHER, ARNULF H.</style></author><author><style face="normal" font="default" size="100%">MÖNIG, STEFAN</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Prognostic Impact of Protein Overexpression of the Proto-oncogene &lt;em&gt;PIM-1&lt;/em&gt; in Gastric Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2009-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4451-4455</style></pages><volume><style face="normal" font="default" size="100%">29</style></volume><issue><style face="normal" font="default" size="100%">11</style></issue><abstract><style  face="normal" font="default" size="100%">Background: PIM kinases are mediators of cytokine signalling pathways in hematopoietic cells and contribute to the progression of certain types of leukemia and solid tumor. Here the prognostic impact of proto-oncogene PIM-1 was analyzed in gastric carcinoma. Patients and Methods: Cancer tissues of 117 patients with potentially curative (R0) resections for gastric cancer were immunohistochemically stained for PIM-1. Results: Cytoplasmic immunoreactivity for PIM-1 in tumor (46%) was higher (p=0.003) compared to that in gastric glands (16%) and foveolae (1%). PIM-1 immunoreactivity in gastric carcinoma correlated with tumor grading (p&lt;0.05) and Laurén category (p&lt;0.02). Overexpression of PIM-1 in gastric glands (p&lt;0.001) was associated with formation of lymph node metastases (p=0.035) and survival (p=0.04). Multivariate analysis of PIM-1 expression in gastric glands confirmed its association with prognosis. Conclusion: Up-regulation of PIM-1 oncogene might be a tumor marker for gastric cancer. The correlation of PIM-1 overexpression in gastric glands with formation of lymph node metastases and survival proposes a prognostic role in gastric cancer.</style></abstract></record></records></xml>