RT Journal Article
SR Electronic
T1 Effects of Carbon-ion Radiotherapy combined with a Novel Histone Deacetylase Inhibitor, Cyclic Hydroxamic-acid-containing Peptide 31 in Human Esophageal Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4433
OP 4438
VO 29
IS 11
A1 KANO, MASAYUKI
A1 YAMADA, SHIGERU
A1 HOSHINO, ISAMU
A1 MURAKAMI, KENTARO
A1 AKUTSU, YASUNORI
A1 SAKATA, HARUHITO
A1 NISHIMORI, TAKANORI
A1 USUI, AKIHIRO
A1 MIYAZAWA, YUKIMASA
A1 KAMADA, TADASHI
A1 TSUJII, HIROHIKO
A1 MATSUBARA, HISAHIRO
YR 2009
UL http://ar.iiarjournals.org/content/29/11/4433.abstract
AB Background: Carbon-ion radiotherapy has several potential advantages over X-rays. This therapy has been applied for various solid tumors including esophageal squamous cell carcinoma (SCC). However, some patients have shown resistance to this treatment. A new effective combined treatment strategy is required for improving the therapeutic effects. Histone deacetylase inhibitors (HDACIs) are new therapeutic candidates for cancer treatment. Several studies have evaluated the combination of X-rays and HDACIs, but, to date, no study has evaluated carbon-ion radiotherapy combined with HDACIs. Materials and Methods: Radio-sensitization to carbon-ion radiotherapy when combined with a novel HDACI cyclic hydroxamic-acid-containing peptide 31(CHAP31) was assessed in human esophageal SCC both in vitro and in vivo. Changes of expression of genes related to DNA repair, by CHAP31 were assessed by quantitative real-time reverse transcriptional PCR analysis. Results: CHAP31 induced sensitization to carbon-ion radiotherapy in vitro and tumor growth was significantly suppressed by the combination of carbon-ion radiotherapy with CHAP31 in comparison to either agent alone in in vivo experiments. CHAP31 inhibited the expression of genes related to DNA repair. Conclusion: CHAP31 sensitizes SCC cells to carbon-ion radiotherapy and this combinatory treatment may be a potentially useful therapeutic strategy for esophageal SCC.