TY - JOUR T1 - Retinol-induced Intestinal Tumorigenesis in <em>Min</em>/+ Mice and Importance of Vitamin D Status JF - Anticancer Research JO - Anticancer Res SP - 4353 LP - 4360 VL - 29 IS - 11 AU - RAGNA BOGEN HETLAND AU - JAN ALEXANDER AU - JENS PETTER BERG AU - CAMILLA SVENDSEN AU - JAN ERIK PAULSEN Y1 - 2009/11/01 UR - http://ar.iiarjournals.org/content/29/11/4353.abstract N2 - The effects of life-long dietary exposure, starting in utero, to high retinol, low vitamin D, or high retinol in combination with low vitamin D on intestinal tumorigenesis in Min/+ mice were investigated. In males, high retinol alone significantly increased the number (2.6-fold) and size (1.3-fold) of small intestinal tumours; in females no significant increase in tumour number or size was seen. In both genders, low vitamin D intake alone did not affect intestinal tumorigenesis. In males, intake of the combined high retinol/low vitamin D diet did not further increase the effects caused by high retinol alone. In females, however, the high retinol/low vitamin D-induced increase in tumour number (3.1-fold) and tumour size (1.5-fold) exceeded that of high retinol alone. In conclusion, a high dietary intake of retinol stimulated intestinal tumorigenesis in Min/+ mice. Furthermore, the results indicate a combined effect of high retinol and low vitamin D on tumorigenesis in females. ER -