RT Journal Article
SR Electronic
T1 MicroRNA Expression in the Progression and Aggressiveness of Papillary Thyroid Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 33
OP 40
DO 10.21873/anticanres.13077
VO 39
IS 1
A1 AGNIESZKA ZEMBSKA
A1 ALEKSANDRA JAWIARCZYK-PRZYBYŁOWSKA
A1 BEATA WOJTCZAK
A1 MAREK BOLANOWSKI
YR 2019
UL http://ar.iiarjournals.org/content/39/1/33.abstract
AB In the last two decades microRNAs have received great attention in research because of their ability to regulate gene expression. Many studies have shown that defects in different microRNA molecules are linked to many diseases; however, their contribution towards thyroid disease has not been fully explored. Herein, we present a short review of the present state of knowledge on microRNAs, such as their origin, their biogenesis and biological function, as well as their differential expression in papillary thyroid carcinoma. Dysregulated microRNA has been closely linked to thyroid dysfunction and oncogenicity leading to this type of thyroid cancer. The effects of Single Nucleotide Polymorphisms in microRNA are also discussed with respect to papillary thyroid carcinoma.