RT Journal Article
SR Electronic
T1 Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Mandibular Squamous Cell Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2343
OP 2348
VO 28
IS 4C
A1 SHIMO, TSUYOSHI
A1 KUBOTA, SATOSHI
A1 GODA, TAKESHI
A1 YOSHIHAMA, YASUTO
A1 KURIO, NAITO
A1 NISHIDA, TAKASHI
A1 NG, POH-SING
A1 ENDO, KOKI
A1 TAKIGAWA, MASAHARU
A1 SASAKI, AKIRA
YR 2008
UL http://ar.iiarjournals.org/content/28/4C/2343.abstract
AB Background: Mandibular bone destruction is a frequent occurrence in oral squamous cell carcinoma. However, the relationship between the bone destruction and associated factors is unclear. Here, the role and diagnostic utility of connective tissue growth factor (CCN2) in bone destruction of the mandible was investigated. Patients and Methods: The production of CCN2 was explored by using immunohistochemistry on paraffin-embedded tissues from 20 cases of mandibular squamous cell carcinoma. The effect of CCN2 on osteoclastogenesis was examined in vitro by using total bone marrow cell populations from male mice. Results: Immunohistochemical analysis showed that CCN2-positive signals were closely associated with destructive invasion of the mandible by oral squamous cell carcinomas. Consistent with these results, recombinant human CCN2 (rCCN2) stimulated tartrate-resistant acid phosphatase (TRAP)-positive osteoclast-like cell formation in vitro. Conclusion: CCN2 can be considered a diagnostic marker and target for treatment in oral osteolytic mandibular squamous cell carcinoma. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved