PT  - JOURNAL ARTICLE
AU  - SHIMO, TSUYOSHI
AU  - KUBOTA, SATOSHI
AU  - GODA, TAKESHI
AU  - YOSHIHAMA, YASUTO
AU  - KURIO, NAITO
AU  - NISHIDA, TAKASHI
AU  - NG, POH-SING
AU  - ENDO, KOKI
AU  - TAKIGAWA, MASAHARU
AU  - SASAKI, AKIRA
TI  - Clinical Significance and Pathogenic Function of Connective Tissue Growth Factor (CTGF/CCN2) in Osteolytic Mandibular Squamous Cell Carcinoma
DP  - 2008 Jul 01
TA  - Anticancer Research
PG  - 2343--2348
VI  - 28
IP  - 4C
4099  - http://ar.iiarjournals.org/content/28/4C/2343.short
4100  - http://ar.iiarjournals.org/content/28/4C/2343.full
SO  - Anticancer Res2008 Jul 01; 28
AB  - Background: Mandibular bone destruction is a frequent occurrence in oral squamous cell carcinoma. However, the relationship between the bone destruction and associated factors is unclear. Here, the role and diagnostic utility of connective tissue growth factor (CCN2) in bone destruction of the mandible was investigated. Patients and Methods: The production of CCN2 was explored by using immunohistochemistry on paraffin-embedded tissues from 20 cases of mandibular squamous cell carcinoma. The effect of CCN2 on osteoclastogenesis was examined in vitro by using total bone marrow cell populations from male mice. Results: Immunohistochemical analysis showed that CCN2-positive signals were closely associated with destructive invasion of the mandible by oral squamous cell carcinomas. Consistent with these results, recombinant human CCN2 (rCCN2) stimulated tartrate-resistant acid phosphatase (TRAP)-positive osteoclast-like cell formation in vitro. Conclusion: CCN2 can be considered a diagnostic marker and target for treatment in oral osteolytic mandibular squamous cell carcinoma. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved