PT - JOURNAL ARTICLE AU - GEORGE RALLIS AU - CONSTANTINOS MOUROUZIS AU - VERONICA PAPAKOSTA AU - ISMINI DONTA AU - DESPINA PERREA AU - EFSTRATIOS PATSOURIS AU - ELEFTHERIOS VAIRAKTARIS TI - Metastases Following Biopsy of Oral Carcinoma in Hamsters and the Role of Local Prebiopsy Bleomycin DP - 2008 Jul 01 TA - Anticancer Research PG - 2253--2257 VI - 28 IP - 4B 4099 - http://ar.iiarjournals.org/content/28/4B/2253.short 4100 - http://ar.iiarjournals.org/content/28/4B/2253.full SO - Anticancer Res2008 Jul 01; 28 AB - Background: This animal study researches the effect of biopsy on metastasis of oral carcinoma. Materials and Methods: Sixty hamsters developed oral tumors after treatment with 9,10-dimethyl-1,2-benzanthracene and were then divided into six groups. Animals of groups 1 and 2 did not receive any treatment, while groups 3-6 were biopsied at the end of the 14th week and groups 5 and 6 also received a prebiopsy intratumoral injection of bleomycin. Animals of groups 1, 3, 5 and 2, 4, 6 were sacrificed at the 17th and 19th week respectively. Specimens of tumors, ipsilateral cervical lymph nodes, lungs and livers were obtained from all animals and histologically examined. Results: All animals developed oral squamous cell carcinomas. In group 4, four out of ten animals showed metastases to the cervical lymph nodes, and one out of four showed a distant metastasis to the lung. Conclusion: Delay of treatment following biopsy can increase the risk of cervical lymph node metastases which can be reduced by an intratumoral administration of bleomycin. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved