PT  - JOURNAL ARTICLE
AU  - FEMIA, ANGELO PIETRO
AU  - PAULSEN, JAN ERIK
AU  - DOLARA, PIERO
AU  - ALEXANDER, JAN
AU  - CADERNI, GIOVANNA
TI  - Correspondence between Flat Aberrant Crypt Foci and Mucin-depleted Foci in Rodent Colon Carcinogenesis
DP  - 2008 Nov 01
TA  - Anticancer Research
PG  - 3771--3775
VI  - 28
IP  - 6A
4099  - http://ar.iiarjournals.org/content/28/6A/3771.short
4100  - http://ar.iiarjournals.org/content/28/6A/3771.full
SO  - Anticancer Res2008 Nov 01; 28
AB  - Background: Flat aberrant crypt foci (flat ACF) and mucin-depleted foci (MDF) are preneoplastic lesions identified in the colon of carcinogen-treated rodents stained with methylene blue (MB) and high iron diamine-alcian blue (HID-AB), respectively. The correspondence between flat ACF and MDF in the same colon of Min mice treated with azoxymethane (AOM) and of F344 rats treated with 1,2-dimethylhydrazine (DMH) was explored. Materials and Methods: The position of each flat ACF was recorded on a digitally constructed photographic map of the MB-stained colon. The same colons were then stained with HID-AB and the position of each MDF was compared with that of flat ACF. Results: The fraction of coincident lesions, identified as both flat ACF and MDF with the two staining methods, was 57% and 42%, in the Min mice and F344 rats, respectively. Flat ACF or MDF not coincident with the two staining methods were either undetectable or ACF with one of the two methods. Conclusion: Flat ACF and MDF show considerable, but not total, overlap. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved