PT  - JOURNAL ARTICLE
AU  - CAN-HONG XIANG
AU  - WEI ZHANG
AU  - YOSHINORI INAGAKI
AU  - KE-MING ZHANG
AU  - YASUHIRO NAKANO
AU  - NORIHIRO KOKUDO
AU  - YASUHIKO SUGAWARA
AU  - JIA-HONG DONG
AU  - MUNEHIRO NAKATA
AU  - WEI TANG
TI  - Measurement of Serum and Tissue <em>Des</em>-γ-carboxyprothrombin in Resectable Hepatocellular Carcinoma
DP  - 2008 Jul 01
TA  - Anticancer Research
PG  - 2219--2224
VI  - 28
IP  - 4B
4099  - http://ar.iiarjournals.org/content/28/4B/2219.short
4100  - http://ar.iiarjournals.org/content/28/4B/2219.full
SO  - Anticancer Res2008 Jul 01; 28
AB  - Background: The total des-γ-carboxyprothrombin (DCP) produced in hepatocellular carcinoma (HCC) and the surrounding non-cancer liver tissue was estimated and the correlation between tissue DCP and serum DCP levels was examined. Patients and Methods: Forty patients with a single primary HCC nodule served as the subjects. The DCP was quantified by electrochemiluminescence immunoassay and the tissue volumes were estimated by computed tomography (CT). Results: The mean tissue DCP in the cancer tissue, non-cancer tissue and the whole HCC specimen was 147,400, 20,200 and 190,000 mAU, respectively, which correlated positively with the serum DCP level (r2=0.657, 0.452, and 0.684, respectively). The DCP expression levels in the cancer and non-cancer liver tissue were also confirmed by immunohistochemical detection of DCP. Conclusion: The elevation of serum DCP levels in HCC patients is influenced by DCP production not only in the cancer tissue, but also in the surrounding non-cancer liver tissue. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved