TY - JOUR T1 - Measurement of Serum and Tissue <em>Des</em>-γ-carboxyprothrombin in Resectable Hepatocellular Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2219 LP - 2224 VL - 28 IS - 4B AU - CAN-HONG XIANG AU - WEI ZHANG AU - YOSHINORI INAGAKI AU - KE-MING ZHANG AU - YASUHIRO NAKANO AU - NORIHIRO KOKUDO AU - YASUHIKO SUGAWARA AU - JIA-HONG DONG AU - MUNEHIRO NAKATA AU - WEI TANG Y1 - 2008/07/01 UR - http://ar.iiarjournals.org/content/28/4B/2219.abstract N2 - Background: The total des-γ-carboxyprothrombin (DCP) produced in hepatocellular carcinoma (HCC) and the surrounding non-cancer liver tissue was estimated and the correlation between tissue DCP and serum DCP levels was examined. Patients and Methods: Forty patients with a single primary HCC nodule served as the subjects. The DCP was quantified by electrochemiluminescence immunoassay and the tissue volumes were estimated by computed tomography (CT). Results: The mean tissue DCP in the cancer tissue, non-cancer tissue and the whole HCC specimen was 147,400, 20,200 and 190,000 mAU, respectively, which correlated positively with the serum DCP level (r2=0.657, 0.452, and 0.684, respectively). The DCP expression levels in the cancer and non-cancer liver tissue were also confirmed by immunohistochemical detection of DCP. Conclusion: The elevation of serum DCP levels in HCC patients is influenced by DCP production not only in the cancer tissue, but also in the surrounding non-cancer liver tissue. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -