RT Journal Article
SR Electronic
T1 Zapotin Prevents Mouse Skin Tumorigenesis During the Stages of Initiation and Promotion
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3705
OP 3709
VO 28
IS 6A
A1 MURIEL CUENDET
A1 CAROL P. OTEHAM
A1 ARUP MAITI
A1 BRUCE A. CRAIG
A1 MARK CUSHMAN
A1 RICHARD C. MOON
A1 JOHN M. PEZZUTO
YR 2008
UL http://ar.iiarjournals.org/content/28/6A/3705.abstract
AB Background: Zapotin, a flavonoid associated with Casimiroa edulis, was isolated as part of a program to discover natural inhibitors of carcinogenesis. Zapote blanco, the fruit of Casimiroa edulis, is consumed in many parts of the world. Zapotin is a non-toxic inducer of cellular differentiation, apoptosis and cell cycle arrest with cultured HL-60 promyelocytic cells. Materials and Methods: An efficient chemical synthesis for zapotin was devised. Using this synthetic material, activity was examined in the two-stage mouse skin carcinogenesis model. Results: Topical zapotin significantly inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced mouse skin tumorigenesis, using the anti-initiation and anti-promotion protocols. Conclusion: Encouraging results from previous and current in vivo studies warrant further investigation of the chemopreventive activity of zapotin. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved