TY - JOUR T1 - Zapotin Prevents Mouse Skin Tumorigenesis During the Stages of Initiation and Promotion JF - Anticancer Research JO - Anticancer Res SP - 3705 LP - 3709 VL - 28 IS - 6A AU - MURIEL CUENDET AU - CAROL P. OTEHAM AU - ARUP MAITI AU - BRUCE A. CRAIG AU - MARK CUSHMAN AU - RICHARD C. MOON AU - JOHN M. PEZZUTO Y1 - 2008/11/01 UR - http://ar.iiarjournals.org/content/28/6A/3705.abstract N2 - Background: Zapotin, a flavonoid associated with Casimiroa edulis, was isolated as part of a program to discover natural inhibitors of carcinogenesis. Zapote blanco, the fruit of Casimiroa edulis, is consumed in many parts of the world. Zapotin is a non-toxic inducer of cellular differentiation, apoptosis and cell cycle arrest with cultured HL-60 promyelocytic cells. Materials and Methods: An efficient chemical synthesis for zapotin was devised. Using this synthetic material, activity was examined in the two-stage mouse skin carcinogenesis model. Results: Topical zapotin significantly inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced mouse skin tumorigenesis, using the anti-initiation and anti-promotion protocols. Conclusion: Encouraging results from previous and current in vivo studies warrant further investigation of the chemopreventive activity of zapotin. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -