@article {CUENDET3705, author = {MURIEL CUENDET and CAROL P. OTEHAM and ARUP MAITI and BRUCE A. CRAIG and MARK CUSHMAN and RICHARD C. MOON and JOHN M. PEZZUTO}, title = {Zapotin Prevents Mouse Skin Tumorigenesis During the Stages of Initiation and Promotion}, volume = {28}, number = {6A}, pages = {3705--3709}, year = {2008}, publisher = {International Institute of Anticancer Research}, abstract = {Background: Zapotin, a flavonoid associated with Casimiroa edulis, was isolated as part of a program to discover natural inhibitors of carcinogenesis. Zapote blanco, the fruit of Casimiroa edulis, is consumed in many parts of the world. Zapotin is a non-toxic inducer of cellular differentiation, apoptosis and cell cycle arrest with cultured HL-60 promyelocytic cells. Materials and Methods: An efficient chemical synthesis for zapotin was devised. Using this synthetic material, activity was examined in the two-stage mouse skin carcinogenesis model. Results: Topical zapotin significantly inhibited 7,12-dimethylbenz(a)anthracene/12-O-tetradecanoylphorbol-13-acetate-induced mouse skin tumorigenesis, using the anti-initiation and anti-promotion protocols. Conclusion: Encouraging results from previous and current in vivo studies warrant further investigation of the chemopreventive activity of zapotin. Copyright{\textcopyright} 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/28/6A/3705}, eprint = {https://ar.iiarjournals.org/content/28/6A/3705.full.pdf}, journal = {Anticancer Research} }