RT Journal Article
SR Electronic
T1 Inhibition of Growth and Induction of Differentiation of Colon Cancer Cells by Peach and Plum Phenolic Compounds
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2067
OP 2076
VO 28
IS 4B
A1 LEA, MICHAEL A.
A1 IBEH, CHINWE
A1 desBORDES, CHARLES
A1 VIZZOTTO, MARCIA
A1 CISNEROS-ZEVALLOS, LUIS
A1 BYRNE, DAVID H.
A1 OKIE, WILLIAM R.
A1 MOYER, MARY P.
YR 2008
UL http://ar.iiarjournals.org/content/28/4B/2067.abstract
AB The action of extracts from anthocyanin-enriched plums and peaches on growth and differentiation was studied with human colon cancer cells. Growth inhibitory effects were observed in Caco-2, SW1116, HT29 and NCM460 cells. In Caco-2 cells but not in the other cells studied there was evidence for increased differentiation as judged by increased activity of alkaline phosphatase and dipeptidyl peptidase. A differentiating effect on Caco-2 cells was not seen with cyanidin or cyanidin-3-glucoside but the action of the fruit extracts was additive with the action of butyrate and with the MEK1/2 inhibitor U0126. Fractionation using C18 indicated activity resided within a fraction containing anthocyanins but further fractionation using LH-20 suggested that most of the activity was in a fraction containing polyphenols other than anthocyanins. It was concluded that several peach and plum phenolic molecules can influence growth and differentiation in human colon cancer cells. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved