PT  - JOURNAL ARTICLE
AU  - LEA, MICHAEL A.
AU  - IBEH, CHINWE
AU  - desBORDES, CHARLES
AU  - VIZZOTTO, MARCIA
AU  - CISNEROS-ZEVALLOS, LUIS
AU  - BYRNE, DAVID H.
AU  - OKIE, WILLIAM R.
AU  - MOYER, MARY P.
TI  - Inhibition of Growth and Induction of Differentiation of Colon Cancer Cells by Peach and Plum Phenolic Compounds
DP  - 2008 Jul 01
TA  - Anticancer Research
PG  - 2067--2076
VI  - 28
IP  - 4B
4099  - http://ar.iiarjournals.org/content/28/4B/2067.short
4100  - http://ar.iiarjournals.org/content/28/4B/2067.full
SO  - Anticancer Res2008 Jul 01; 28
AB  - The action of extracts from anthocyanin-enriched plums and peaches on growth and differentiation was studied with human colon cancer cells. Growth inhibitory effects were observed in Caco-2, SW1116, HT29 and NCM460 cells. In Caco-2 cells but not in the other cells studied there was evidence for increased differentiation as judged by increased activity of alkaline phosphatase and dipeptidyl peptidase. A differentiating effect on Caco-2 cells was not seen with cyanidin or cyanidin-3-glucoside but the action of the fruit extracts was additive with the action of butyrate and with the MEK1/2 inhibitor U0126. Fractionation using C18 indicated activity resided within a fraction containing anthocyanins but further fractionation using LH-20 suggested that most of the activity was in a fraction containing polyphenols other than anthocyanins. It was concluded that several peach and plum phenolic molecules can influence growth and differentiation in human colon cancer cells. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved