<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">LEA, MICHAEL A.</style></author><author><style face="normal" font="default" size="100%">IBEH, CHINWE</style></author><author><style face="normal" font="default" size="100%">desBORDES, CHARLES</style></author><author><style face="normal" font="default" size="100%">VIZZOTTO, MARCIA</style></author><author><style face="normal" font="default" size="100%">CISNEROS-ZEVALLOS, LUIS</style></author><author><style face="normal" font="default" size="100%">BYRNE, DAVID H.</style></author><author><style face="normal" font="default" size="100%">OKIE, WILLIAM R.</style></author><author><style face="normal" font="default" size="100%">MOYER, MARY P.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition of Growth and Induction of Differentiation of Colon Cancer Cells by Peach and Plum Phenolic Compounds</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2008-07-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">2067-2076</style></pages><volume><style face="normal" font="default" size="100%">28</style></volume><issue><style face="normal" font="default" size="100%">4B</style></issue><abstract><style  face="normal" font="default" size="100%">The action of extracts from anthocyanin-enriched plums and peaches on growth and differentiation was studied with human colon cancer cells. Growth inhibitory effects were observed in Caco-2, SW1116, HT29 and NCM460 cells. In Caco-2 cells but not in the other cells studied there was evidence for increased differentiation as judged by increased activity of alkaline phosphatase and dipeptidyl peptidase. A differentiating effect on Caco-2 cells was not seen with cyanidin or cyanidin-3-glucoside but the action of the fruit extracts was additive with the action of butyrate and with the MEK1/2 inhibitor U0126. Fractionation using C18 indicated activity resided within a fraction containing anthocyanins but further fractionation using LH-20 suggested that most of the activity was in a fraction containing polyphenols other than anthocyanins. It was concluded that several peach and plum phenolic molecules can influence growth and differentiation in human colon cancer cells. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>