@article {KAWAGUCHI-IHARA87, author = {NORIKO KAWAGUCHI-IHARA and YAN ZHAO and SUZUNE NAKAMURA and KEIKO SUZUKI and YI ZHANG and SHUJI TOHDA and IKUO MUROHASHI}, title = {Chloroquine Inhibits Self-Renewal of Blast Progenitors Synergistically With Phytochemicals or Nonsteroidal Anti-inflammatory Drugs in Hematological Malignant Cell Lines}, volume = {39}, number = {1}, pages = {87--98}, year = {2019}, doi = {10.21873/anticanres.13083}, publisher = {International Institute of Anticancer Research}, abstract = {Background: This study examined whether and how chloroquine inhibits blast progenitor self-renewal (SR) synergistically with phytochemicals or nonsteroidal anti-inflammatory drugs in seven hematological malignant cell lines. Materials and Methods: Vitamin C, resveratrol, cyclo-oxygenase inhibitor NS-398 and indomethacin heptyl ester (Ind) were added to cell culture with or without 3 μM chloroquine. Results: Chloroquine synergistically inhibited blast colony formation in methylcellulose with vitamin C, resveratrol, NS-398 and Ind in one, two, none and one cell lines, respectively, in a total of four out of 28 conditions. Chloroquine synergistically inhibited blast progenitor SR in suspension with vitamin C, resveratrol, NS-398 and Ind in four, six, one and five cell lines, respectively, in a total of 16 out of 28 conditions. In contrast, chloroquine abolished SR inhibition by another agent in four out of 28 conditions. Conclusion: Chloroquine exerted a marked synergistic inhibition of blast progenitor SR, but not blast colony formation.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/39/1/87}, eprint = {https://ar.iiarjournals.org/content/39/1/87.full.pdf}, journal = {Anticancer Research} }