TY - JOUR T1 - Down-regulated Expression of RhoA in Human Conventional Renal Cell Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2039 LP - 2043 VL - 28 IS - 4B AU - YEONG-SHIAU PU AU - CHUANG-WEI WANG AU - GUANG-YAW LIU AU - YI-ZIH KUO AU - CHAO-YUAN HUANG AU - WANG-YI KANG AU - CHIA-TUNG SHUN AU - CHIA-CHI LIN AU - WEN-JENG WU AU - TZYH-CHYUAN HOUR Y1 - 2008/07/01 UR - http://ar.iiarjournals.org/content/28/4B/2039.abstract N2 - Background: Renal cell carcinoma (RCC) is the most common cancer in adult kidney. Delayed diagnosis may result in progression and metastasis. Markers for early detection of RCC are lacking. The small GTPase RhoA has been implicated in the regulation of cell morphology, motility and transformation, but the role of RhoA in tumorigenesis of RCC remains unclear. In this study, the significance of RhoA expression in human RCC was characterized. Materials and Methods: RhoA mRNA and protein expressions were examined by real-time polymerase chain reaction (PCR) and immunohistochemistry respectively in 46 pairs of tissues. Results: Real-time PCR revealed that RhoA mRNA expression was significantly lower in cancerous as compared to normal tissues (p=0.036). RhoA protein expression was significantly higher in normal than in cancerous tissues (p=0.032). However, RhoA expression did not correlate with age, differentiation grade or TNM stage (all p>0.05). Conclusion: RhoA down-regulation may be involved in human renal tumorigenesis. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -