PT  - JOURNAL ARTICLE
AU  - SUSANNE MARKERT
AU  - SILKE LASSMANN
AU  - BORIS GABRIEL
AU  - MAXIMILIAN KLAR
AU  - MARTIN WERNER
AU  - GERALD GITSCH
AU  - FELIX KRATZ
AU  - ANNETTE HASENBURG
TI  - Alpha-folate Receptor Expression in Epithelial Ovarian Carcinoma and Non-neoplastic Ovarian Tissue
DP  - 2008 Nov 01
TA  - Anticancer Research
PG  - 3567--3572
VI  - 28
IP  - 6A
4099  - http://ar.iiarjournals.org/content/28/6A/3567.short
4100  - http://ar.iiarjournals.org/content/28/6A/3567.full
SO  - Anticancer Res2008 Nov 01; 28
AB  - Background: The goal of this study was to evaluate the expression pattern and intracellular localization of alpha-folate receptor (α-FR) protein in human ovarian carcinoma compared with non-neoplastic ovarian tissue. Materials and Methods: Using immunohistochemistry (IHC), α-FR protein expression was analyzed in specimens of 104 human ovarian carcinomas and 30 non-neoplastic ovaries. Results: In 97% of the ovarian carcinomas, clear α-FR protein expression was detected (14% weak, 39% moderate, 44% strong). In the non-neoplastic ovaries, no (37%) or only weak (63%) expression was observed (p<0.0001). The tumor cells were characterized by a diffuse and homogeneous staining pattern. In tumor and non-tumor tissue, α-FR protein was detected predominantly in the cellular cytoplasm. In 41% of the ovarian carcinomas, cytoplasmic expression was localized towards the outer boarders of the invasive tumor cells and 30% exhibited additional nuclear α-FR protein expression. Conclusion: Compared with non-neoplastic ovaries, α-FR protein is overexpressed in human ovarian carcinoma tissue. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved