TY - JOUR T1 - Fatal Thrombocytopenia after Oxaliplatin-based Chemotherapy JF - Anticancer Research JO - Anticancer Res SP - 3115 LP - 3117 VL - 28 IS - 5B AU - YU-YUN SHAO AU - RUEY-LONG HONG Y1 - 2008/09/01 UR - http://ar.iiarjournals.org/content/28/5B/3115.abstract N2 - Oxaliplatin-related thrombocytopenia is considered rare and mostly self-limited. We present the first reported fatal case due to this complication. A 64-year-old patient with metastatic colon cancer was admitted for his 24th course of chemotherapy with oxaliplatin and 24-hour infusion of fluorouracil and leucovorin. Consciousness changed on the next evening and deteriorated to deep coma within hours. Computed tomography revealed large intracranial hemorrhage with brain herniation. Hemogram showed severe thrombocytopenia, which was considered to be associated with oxaliplatin. The patient died six days later. The incidence of oxaliplatin-related thrombo-cytopenia may have been underestimated and its severity long neglected. Other hypersensitivity reactions may precede its onset. Early hemogram examination during hypersensitivity reaction to oxaliplatin may provide early diagnosis and the prevention of the possible fatal consequences. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -