RT Journal Article
SR Electronic
T1 Association Between Genetic Polymorphisms and Ovarian Cancer Risk
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3079
OP 3081
VO 28
IS 5B
A1 LAETITIA DELORT
A1 NASSÉRA CHALABI
A1 SAMIR SATIH
A1 NADÈGE RABIAU
A1 FABRICE KWIATKOWSKI
A1 YVES-JEAN BIGNON
A1 DOMINIQUE J BERNARD-GALLON
YR 2008
UL http://ar.iiarjournals.org/content/28/5B/3079.abstract
AB Background: The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. Patients and Methods: A case-control study was conducted to investigate the role of these polymorphisms in ovarian cancer risk. The participants were genotyped for eleven polymorphisms in seven genes involved in estrogen and xenobiotic metabolism (CYP1A1, CYP1B1, COMT, GSTP1, NAT2, estrogen receptor ESR, and progesterone receptor PGR). Results and Conclusion: The odds ratios for ovarian cancer risk were 2.02 (95% confidence interval [CI] = 1.14-3.56) in the NAT2 intermediate acetylators and 4.07 (95% CI = 1.30-12.70) in the slow acetylators. At least three cumulative high-risk genotypes increased ovarian cancer risk, but not significantly. More studies are needed in order to define genetic ovarian risk factors. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved