TY - JOUR T1 - Association Between Genetic Polymorphisms and Ovarian Cancer Risk JF - Anticancer Research JO - Anticancer Res SP - 3079 LP - 3081 VL - 28 IS - 5B AU - LAETITIA DELORT AU - NASSÉRA CHALABI AU - SAMIR SATIH AU - NADÈGE RABIAU AU - FABRICE KWIATKOWSKI AU - YVES-JEAN BIGNON AU - DOMINIQUE J BERNARD-GALLON Y1 - 2008/09/01 UR - http://ar.iiarjournals.org/content/28/5B/3079.abstract N2 - Background: The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. Patients and Methods: A case-control study was conducted to investigate the role of these polymorphisms in ovarian cancer risk. The participants were genotyped for eleven polymorphisms in seven genes involved in estrogen and xenobiotic metabolism (CYP1A1, CYP1B1, COMT, GSTP1, NAT2, estrogen receptor ESR, and progesterone receptor PGR). Results and Conclusion: The odds ratios for ovarian cancer risk were 2.02 (95% confidence interval [CI] = 1.14-3.56) in the NAT2 intermediate acetylators and 4.07 (95% CI = 1.30-12.70) in the slow acetylators. At least three cumulative high-risk genotypes increased ovarian cancer risk, but not significantly. More studies are needed in order to define genetic ovarian risk factors. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -