TY - JOUR T1 - Pleomorphic Adenoma of Salivary Glands Does Not Appear to Be a BRCA-1-dependent Tumour in a Polish Cohort JF - Anticancer Research JO - Anticancer Res SP - 3011 LP - 3013 VL - 28 IS - 5B AU - JAKUB LUBIŃSKI AU - CZESŁAWA TARNOWSKA AU - EWA JAWOROWSKA AU - TOMASZ BYRSKI AU - ANNA JAKUBOWSKA AU - BOGDAN GÓRSKI AU - STANISŁAW BIEŃ AU - JACEK SYGUT AU - STANISŁAW GÓŹDŹ AU - MONIKA SIOŁEK AU - MIECZYSŁAW SULIKOWSKI AU - JAN LUBIŃSKI Y1 - 2008/09/01 UR - http://ar.iiarjournals.org/content/28/5B/3011.abstract N2 - Background: The aim of the study was to examine whether pleomorphic adenoma of salivary glands can occur on the basis of constitutional BRCA-1 mutations. Materials and Methods: Two hundred and sixty-eight patients affected by mixed tumour of salivary glands were examined for occurrence of three BRCA-1 mutations dominating in Poland. Results: BRCA-1 mutation was detected in only one of the patients, a female affected by breast cancer and pleomorphic adenoma of parotid gland. Parotid gland tumour showed clinical and histopathological features of typical pleomorphic adenoma with no morphological features of high-grade malignancy, which are characteristic of BRCA-1-dependent tumours. Conclusion: Considering the low frequency of BRCA-1 mutation in the examined group and also the absence of features characterizing BRCA-1-dependent tumours in the only BRCA-1-positive case, pleomorphic adenoma of salivary glands should not be recognized as a BRCA-1 dependent tumour. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -