TY - JOUR T1 - Expression and Prognostic Significance of PDCD4 in Human Epithelial Ovarian Carcinoma JF - Anticancer Research JO - Anticancer Res SP - 2991 LP - 2996 VL - 28 IS - 5B AU - XIAOYAN WANG AU - ZENGTAO WEI AU - FEI GAO AU - XIA ZHANG AU - CHENGJUN ZHOU AU - FALIANG ZHU AU - QUN WANG AU - QI GAO AU - CHUNHONG MA AU - WENSHENG SUN AU - BEIHUA KONG AU - LINING ZHANG Y1 - 2008/09/01 UR - http://ar.iiarjournals.org/content/28/5B/2991.abstract N2 - Background: Programmed cell death 4 (PDCD4) is a newly discovered tumor suppressor. The aim of this study was to investigate the expression and prognostic significance of PDCD4 in epithelial ovarian cancer. Materials and Methods: PDCD4 expression in 20 normal human ovaries and 69 serous ovarian tumors was examined by RT-PCR and immunohistochemistry. The relationships between PDCD4 expression, clinicopathological data and patient survival were evaluated. Results: PDCD4 expression was found to be lost or significantly lower in serous cystadenocarcinomas compared with that in normal ovaries and serous cystadenomas (p<0.05). The loss or reduction of PDCD4 expression in serous cystadenocarcinomas was significantly associated with higher pathological grade (p=0.0118) and poorer disease-specific survival of patients (p=0.0011). Multivariant Cox regression analysis revealed that PDCD4 expression was an independent prognostic factor for serous cystadenocarcinoma. Conclusion: Lost or reduced PDCD4 expression is associated with the progression of serous cystadenocarcinomas and may serve as an important prognostic marker. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -