RT Journal Article
SR Electronic
T1 Morphological and Molecular Profiles and Pathways in Bladder Neoplasms
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2893
OP 2900
VO 28
IS 5B
A1 ANTONIO LOPEZ-BELTRAN
A1 LIANG CHENG
A1 ROBERTA MAZZUCCHELLI
A1 MARISTELLA BIANCONI
A1 ANA BLANCA
A1 MARINA SCARPELLI
A1 RODOLFO MONTIRONI
YR 2008
UL http://ar.iiarjournals.org/content/28/5B/2893.abstract
AB After several decades of use of the Wealth Health Organization (WHO) 1973 grading system for bladder neoplasms (1973 WHO), a new grading system was adopted in 2004 by the WHO (2004 WHO). Some leading experts in the field of urogenital pathology have expressed their concerns with the 2004 WHO categorization system, both with regard to the nomenclature and the grading categories used. Several molecular and genetic studies have provided another perspective on the classification of urothelial neoplasms. The two most important developments are the identification of a mutation in the fibroblast growth factor receptor 3 gene in more than 50% of urothelial carcinomas and the discovery of cDNA profiles characteristic of different subsets of bladder cancer. There is strong correlation between the molecular findings and the 2004 WHO classification and prognosis. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved