TY - JOUR T1 - Surgical Treatment of Intrathyroid Metastases: Preliminary Results of a Multicentric Study JF - Anticancer Research JO - Anticancer Res SP - 2885 LP - 2888 VL - 28 IS - 5B AU - FILIPPO CALZOLARI AU - PAOLA VINCENZA SARTORI AU - CARLO TALARICO AU - DOMENICO PARMEGGIANI AU - EDOARDO BERETTA AU - LUCIANO PEZZULLO AU - GIORGIO BOVO AU - PASQUALE SPERLONGANO AU - MASSIMO MONACELLI AU - ROBERTA LUCCHINI AU - CLAUDIA MISSO AU - ANGELA GURRADO AU - MICHELE D'AJELLO AU - FRANCO UGGERI AU - EFISIO PUXEDDU AU - PIERGIORGIO NASI AU - MARIO TESTINI AU - LODOVICO ROSATO AU - ALFONSO BARBARISI AU - NICOLA AVENIA Y1 - 2008/09/01 UR - http://ar.iiarjournals.org/content/28/5B/2885.abstract N2 - Background: Intrathyroid metastases (ITM) are rare and usually have a dismal prognosis. The aim of this study was to detect which neoplasms metastasize most often to the thyroid gland, their clinical features and treatment options. Materials and Methods: Retrospective analysis of clinical files of 17,122 patients submitted to surgery for thyroid disease between 1995 and 2005. Twenty-five patients (median age 61 years) were affected by ITM. Results: The site of the primary tumor was: kidney (15), lung (4), colon (3), breast (1), melanoma (1), and unknown in 1 patient. Ten patients (40%) complained of preoperative symptoms, in the others, thyroid involvement was incidentally discovered during the follow-up for the primary cancer. Twenty patients (80%) underwent total thyroidectomy, 3 received thyroid lobectomy and 2 palliative procedures. Morbidity was 16%, mortality was nil. The median follow-up was 24 months. Conclusion: ITM should always be suspected in any patient with a previous history of malignancy. Fine-needle agobiopsy (FNAB) with immunohistochemical stains may help in preoperative workup. A long delay between the primary tumor and the recurrence warrants surgery and total thyroidectomy seems to be the treatment of choice because of the multifocality of metastasis to the thyroid gland. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -