PT - JOURNAL ARTICLE AU - ROGER TELL AU - CHRISTER SEDERHOLM AU - CLAES KLINTENBERG AU - LARS FRANKSSON AU - EVA BRANDÉN AU - GUNNAR HILLERDAL AU - ULF LÖNN AU - CARL-JOHAN LINDÉN AU - SVEN-BÖRJE EWERS AU - KRISTINA LAMBERG AU - EVA MRAZEK AU - BRITTA LÖDÉN AU - ANDERS SJÖGREN AU - THOMAS LINNÉ AU - SIGNE FRIESLAND AU - FLORIN SIRZÉN TI - Multicentre Phase II Trial of Paclitaxel and Carboplatin with Concurrent Radiotherapy in Locally Advanced Non-small Cell Lung Cancer DP - 2008 Sep 01 TA - Anticancer Research PG - 2851--2857 VI - 28 IP - 5B 4099 - http://ar.iiarjournals.org/content/28/5B/2851.short 4100 - http://ar.iiarjournals.org/content/28/5B/2851.full SO - Anticancer Res2008 Sep 01; 28 AB - Aim: To evaluate weekly induction chemotherapy followed by weekly concomitant chemoradiotherapy in a multicentre phase II study of patients with unresectable stage III non-small cell lung cancer (NSCLC; stage wet IIIB excluded). Patients and Methods: Eligible patients received three weekly cycles of paclitaxel 100 mg/m2 and carboplatin AUC2 followed by six weekly cycles of paclitaxel 60 mg/m2 and carboplatin AUC2 in combination with thoracic radiotherapy (2 Gy per fraction and day to a total dose of 60 Gy). Results: Sixty-four patients (40 males and 24 females) with a median age of 63 years (range, 43-79 years) entered the study. T and N stage were distributed as follows: T1 2 patients (3.2%), T2 10 patients (15.6%), T3 15 patients (23.4%), T4 37 patients (57.8%); N0 10 patients (15.6%), N1 1 patient (1.6%), N2 26 patients (40.6%), N3 26 patients (40.6%), and N missing 1 patient (1.6%). Seven patients (10.9%) suffered from grade 3/4 oesophagitis. Grade 1/2 oesophagitis occurred in 36 patients (56.3%) and pneumonitis grade 1/2 occurred in 10 patients (15.6%). Sixty-three patients were evaluated on an intent-to-treat basis. The overall response rate was 74.6% . The median time to progression was 247 days and median overall survival was 461 days. According to subgroup analyses, no statistically significant differences were noted according to gender, age (<65 vs. ≥65 years), performance status, histology, or study centre. Conclusion: Induction chemotherapy followed by concurrent chemoradiotherapy with weekly cycles of paclitaxel and carboplatin is feasible and generates moderate toxicity. Efficacy is comparable to other recently published regimens. However, prognosis remains, in general, poor for this group of patients and further work to develop better therapy is required. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved