RT Journal Article
SR Electronic
T1 Chemopreventive Effects of Anastrozole in a Premenopausal Breast Cancer Model
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2819
OP 2823
VO 28
IS 5A
A1 PETER KUBATKA
A1 VLADIMÍRA SADLOŇOVÁ
A1 KAROL KAJO
A1 GABRIELA NOSÁL'OVÁ
A1 DANIELA OSTATNÍKOVÁ
A1 KATARÍNA ADAMICOVÁ
YR 2008
UL http://ar.iiarjournals.org/content/28/5A/2819.abstract
AB Background: Monotherapy with aromatase inhibitors has no established role in premenopausal breast cancer in women and is an area of future exploration. Materials and Methods: In this study, chemopreventive effects of anastrozole in the model of N-methyl-N-nitrosourea-induced premenopausal mammary carcinogenesis in female rats were evaluated. Anastrozole was dietarily administered at two concentrations: 0.05 mg/kg (ANA 0.05) and 0.5 mg/kg (ANA 0.5). Basic parameters of experimental carcinogenesis and side-effects on selected organs after anastrozole treatment in animals were assessed. Results: In the ANA 0.5 group, anastrozole suppressed tumor incidence by 40% (p<0.05) and tumor frequency by 57% (p<0.01), as well as lengthening the latency period by 10 days (p=0.084) compared to control animals. Adverse effects of anastrozole on the genital system (uterus and vagina) and lipid and bone metabolism in rats were not found. Anastrozole did not alter serum concentrations of estradiol, testosterone or dehydroepiandrosterone in animals. An increase in the body weight gain of rats in the ANA 0.5 group compared with the controls (p<0.01) was observed. Conclusion: This study is the first about the antineoplastic effects of anastrozole in a model of premenopausal mammary carcinogenesis in female rats.