RT Journal Article
SR Electronic
T1 DNA Repair Gene <em>ERCC2, XPC, XRCC1, XRCC3</em> Polymorphisms and Associations with Bladder Cancer Risk in a French Cohort
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1853
OP 1856
VO 28
IS 3B
A1 LUC FONTANA
A1 RÉMY BOSVIEL
A1 LAETITIA DELORT
A1 LAURENT GUY
A1 NASSÉRA CHALABI
A1 FABRICE KWIATKOWSKI
A1 SAMIR SATIH
A1 NADÈGE RABIAU
A1 JEAN-PAUL BOITEUX
A1 ALAIN CHAMOUX
A1 YVES-JEAN BIGNON
A1 DOMINIQUE J. BERNARD-GALLON
YR 2008
UL http://ar.iiarjournals.org/content/28/3B/1853.abstract
AB In polygenic diseases, association studies look for genetic variation such as polymorphisms in low penetrance genes, i.e. genes in interaction with environmental factors. DNA repair systems that protect the genome from deleterious endogenous and exogenous damage have been shown to significantly reduce activity. In particular, enzymes of the nucleotide excision repair pathway are suspected to be implicated in cancer. In this study bladder cancer which is viewed as a polygenic disease was investigated. The functional polymorphisms of four DNA repair genes, excision repair cross-complementing group 2 (ERCC2), Xeroderma Pigmentosum group C (XPC), and X-ray repair cross-complementing groups 1 and 3 (XRCC1 and XRCC3) were analyzed. The studied population included 51 bladder cancer cases and 45 controls. The genotyping of six SNP (single nucleotide polymorphism) was carried out on these populations with the MGB (Minor Groove Binder) probe technique which uses allelic discrimination with the Taqman® method. The Gln allele of the XPC 939 polymorphism was found to be associated with an increase in bladder cancer risk. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved