RT Journal Article SR Electronic T1 Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 73 OP 79 DO 10.21873/anticanres.13081 VO 39 IS 1 A1 SAMULI I. NISSINEN A1 ANTTI ROINE A1 LAURI HOKKINEN A1 MARKUS KARJALAINEN A1 MARKUS VENÄLÄINEN A1 HELI HELMINEN A1 RIIKKA NIEMI A1 TERHO LEHTIMÄKI A1 TUOMO RANTANEN A1 NIKU OKSALA YR 2019 UL http://ar.iiarjournals.org/content/39/1/73.abstract AB Background/Aim: Most pancreatic cancer patients are diagnosed at an advanced stage, since the diagnosis is demanding. Field asymmetric waveform ion mobility spectrometry (FAIMS) is a sensitive technique used for the detection of volatile organic compounds (VOC). We evaluated the ability of FAIMS to discriminate between pancreatic cancer and healthy controls from a urine sample. Patients and Methods: For a proof-of-concept study in three Finnish hospitals, 68 patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis, 8 with pancreatic pre-malign lesions and 52 healthy controls were prospectively recruited. Urine samples were collected at the time of diagnosis and stored at −70°C. The samples were subsequently measured with FAIMS. The data were processed with linear discriminant analysis and cross-validated with leave-one-out cross-validation. Results: FAIMS distinguished pancreatic cancer from controls with a sensitivity of 79% and specificity of 79%. Conclusion: As a non-invasive and rapid urine test, FAIMS can discriminate patients with pancreatic cancer from healthy controls.