PT  - JOURNAL ARTICLE
AU  - SAMULI I. NISSINEN
AU  - ANTTI ROINE
AU  - LAURI HOKKINEN
AU  - MARKUS KARJALAINEN
AU  - MARKUS VENÄLÄINEN
AU  - HELI HELMINEN
AU  - RIIKKA NIEMI
AU  - TERHO LEHTIMÄKI
AU  - TUOMO RANTANEN
AU  - NIKU OKSALA
TI  - Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis
AID  - 10.21873/anticanres.13081
DP  - 2019 Jan 01
TA  - Anticancer Research
PG  - 73--79
VI  - 39
IP  - 1
4099  - http://ar.iiarjournals.org/content/39/1/73.short
4100  - http://ar.iiarjournals.org/content/39/1/73.full
SO  - Anticancer Res2019 Jan 01; 39
AB  - Background/Aim: Most pancreatic cancer patients are diagnosed at an advanced stage, since the diagnosis is demanding. Field asymmetric waveform ion mobility spectrometry (FAIMS) is a sensitive technique used for the detection of volatile organic compounds (VOC). We evaluated the ability of FAIMS to discriminate between pancreatic cancer and healthy controls from a urine sample. Patients and Methods: For a proof-of-concept study in three Finnish hospitals, 68 patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis, 8 with pancreatic pre-malign lesions and 52 healthy controls were prospectively recruited. Urine samples were collected at the time of diagnosis and stored at −70°C. The samples were subsequently measured with FAIMS. The data were processed with linear discriminant analysis and cross-validated with leave-one-out cross-validation. Results: FAIMS distinguished pancreatic cancer from controls with a sensitivity of 79% and specificity of 79%. Conclusion: As a non-invasive and rapid urine test, FAIMS can discriminate patients with pancreatic cancer from healthy controls.