RT Journal Article
SR Electronic
T1 Biological Activity and Clinical Implications of the Matrix Metalloproteinases
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1389
OP 1397
VO 28
IS 2B
A1 M. RYDLOVA
A1 L. HOLUBEC, Jr.
A1 M. LUDVIKOVA, Jr.
A1 D. KALFERT
A1 J. FRANEKOVA
A1 C. POVYSIL
A1 M. LUDVIKOVA
YR 2008
UL http://ar.iiarjournals.org/content/28/2B/1389.abstract
AB The family of human matrix metalloproteinases (MMPs) comprises several tightly regulated classes of proteases. These enzymes and their specific inhibitors play important roles in tumour progression and the metastatic process by facilitating extracellular matrix degradation. As scientific understanding of the MMPs has advanced, therapeutic strategies focusing on blocking these enzymes by matrix metalloproteinase inhibitors have rapidly developed. Low molecular weight tissue inhibitors of matrix metalloproteinase (TIMPs) represent a new therapeutic approach for the treatment of individual types of cancer. This paper aims to briefly summarize current knowledge about the role of MMPs in select non-tumorous lesions, tumor invasion and metastasis. The perspectives in therapeutic intervention in cancer are also mentioned. The role of MMPs in diagnosis and prognosis of colorectal and thyroid cancer is discussed in detail. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved