TY - JOUR T1 - Increased Cancer Mortality in Type 2 Diabetes (ZODIAC-3) JF - Anticancer Research JO - Anticancer Res SP - 1373 LP - 1375 VL - 28 IS - 2B AU - G.W.D. LANDMAN AU - L.J. UBINK-VELTMAAT AU - N. KLEEFSTRA AU - B.J. KOLLEN AU - H.J.G. BILO Y1 - 2008/03/01 UR - http://ar.iiarjournals.org/content/28/2B/1373.abstract N2 - Background: It is unclear whether there is a relationship between type two diabetes and cancer mortality. It also is unclear whether obesity and body mass index (BMI) are associated with cancer in type 2 diabetes patients. Patients and Methods: In 1998, 1,145 patients with type two diabetes mellitus were enrolled in the Zwolle Outpatient Diabetes project Intergrating Available Care (ZODIAC) study. In this project, general practitioners (GPs) were assisted by hospital-based diabetes specialist nurses. Vital status was assessed in September 2004. The cancer mortality rate was evaluated using standardized mortality ratio (SMR) and its association with BMI (kg/m2) and obesity (>30 kg/m2) with the Cox proportional hazard ratio. Results: The median follow-up time was 5.8 years. A total of 335 patients had died, of whom 70 died from malignancy. The SMR for cancer mortality was 1.38 (95% CI 1.07-1.75). BMI and obesity were not associated with cancer death. Conclusion: An increased cancer mortality rate was found in type two diabetes mellitus patients but there was no significant association between BMI or obesity and cancer mortality. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -