TY - JOUR T1 - Impact of Palliative Gastrectomy in Patients with Incurable Advanced Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 1309 LP - 1315 VL - 28 IS - 2B AU - CHIKARA KUNISAKI AU - HIROCHIKA MAKINO AU - RYO TAKAGAWA AU - TAKASHI OSHIMA AU - YASUHIKO NAGANO AU - SHOICHI FUJII AU - HIROTOSHI AKIYAMA AU - YUICHI OTSUKA AU - HIDETAKA A. ONO AU - TAKASHI KOSAKA AU - YASUSHI ICHIKAWA AU - HIROSHI SHIMADA Y1 - 2008/03/01 UR - http://ar.iiarjournals.org/content/28/2B/1309.abstract N2 - Background: The efficacy of palliative gastrectomy for incurable advanced gastric cancer remains debatable. Patients and Methods: The study group comprised a series of 164 patients who had undergone palliative gastrectomy. Survival and prognostic factors were evaluated by univariate and multivariate analyses. Results: The median survival time was 9 months. Univariate analysis identified the following as factors that adversely affected survival: larger and deeper undifferentiated tumors; peritoneal, hematogenous, or remaining lymph-node metastasis; a large number of non-curative factors; less extensive lymph-node dissection; and an absence of chemotherapy. The Cox proportional regression hazard model recognized histological type, hematogenous metastasis, peritoneal metastasis and chemotherapy as independent factors. Moreover, the number of non-curative factors independently affected the disease-specific survival. In patients with a single non-curative factor, histological type and adjuvant chemotherapy were independent prognostic factors. Conclusion: A randomized controlled study should be conducted in advanced gastric cancer patients with a single non-curative factor to confirm the usefulness of palliative gastrectomy followed by chemotherapy shown here. Copyright© 2008 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -